反应详情

To a suspension of 3-chlorobenzaldehyde (50 g, 355 mmol) and hydroxylamine hydrochloride (38 g, 543 mmol) in ethanol (200 mL) containing sodium acetate (46 g, 558 mmol) was heated under reflux for 3 h. After 30 min stirring at room temperature a white solid precipitated and the resulting mixture was then diluted with water and acidified with HCl (4 N). The white precipitate was then filtered off, washed with water and dried under high vacuum to afford the title compound (54 g, 98%) which was obtained as a white solid. Mp: 64-66° C.

1. temperaturewas heated
2. temperatureunder reflux for 3 h
3. customprecipitated
4. additionthe resulting mixture was then diluted with water
5. filtrationThe white precipitate was then filtered off
6. washwashed with water
7. customdried under high vacuum