反应详情

A solution of 3 g Piperidin-4-yl-carbamic acid tert-butyl ester and 2.5 g 4-Chloropyridine in 9 ml n-butanol/water/NEt3 1:1:1 was heated at 100° C. for 48 h. Then the solution was cooled to RT diluted with DCM and washed with NaHCO3 solution and water. The organic layer was dried over Na2SO4, filtered, and the solvent was removed under reduced pressure. Chromatographic purification of the residue on silica with DCM as eluent gave after evaporation of the fractions containing the product a white foam. Yield 1.7 g.

1. washwashed with NaHCO3 solution and water
2. dry with materialThe organic layer was dried over Na2SO4
3. filtrationfiltered
4. customthe solvent was removed under reduced pressure
5. customChromatographic purification of the residue on silica with DCM as eluent
6. customgave
7. customafter evaporation of the fractions
8. additioncontaining the product a white foam