HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Bromoacetyl bromide | HCID 61147 | — |
| Reactant | 2-Amino-5-chloropyridine | HCID 66174 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 2-Bromo-N-(5-chloro-2-pyridinyl)acetamide | HCID 3421110 | — |
Reaction Steps
To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 ml pyridine in 30 ml toluene, 8 g bromo-acetyl bromide dissolved in 10 ml toluene was added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recristallized from toluene to yield a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07429581B2 |
| Source dataset | uspto-grants-2008_09 |
| ORD ID | ord-9144a3b8e0514b2aa093ac48a0c5ecd9 |
| Source note | uspto-grants-2008_09 |