反应详情

To a solution of 5 g 5-Chloro-pyridin-2-ylamine and 1.5 ml pyridine in 30 ml toluene, 8 g bromo-acetyl bromide dissolved in 10 ml toluene was added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recristallized from toluene to yield a white solid.

1. additionwas added dropwise under ice cooling
2. customAfter 2 h the precipitate was isolated by filtration
3. customto yield a white solid