反应详情

In a 40 mL vial equipped with a stir bar was placed (16) (1.09 g, 4.27 mmol), tetrahydrofuran (10 mL), water (10 mL) and sodium borohydride (485 mg, 12.8 mmol). The mixture was stirred at room temperature for 2 hours and then quenched with water (60 mL). After extractions with ethyl acetate (3×50 mL), the organic portions were combined, washed with brine (75 mL), dried (MgSO4), concentrated. The resulting solid was dried in a high vacuum oven for 5 hours at 45° C. and 945 mg (86% yield) of (17) was isolated.

1. customIn a 40 mL vial equipped with a stir bar
2. customquenched with water (60 mL)
3. extractionAfter extractions with ethyl acetate (3×50 mL)
4. washwashed with brine (75 mL)
5. dry with materialdried (MgSO4)
6. concentrationconcentrated
7. customThe resulting solid was dried in a high vacuum oven for 5 hours at 45° C.