Trifluoroacetic acid → (2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

HRID 332599Notes

Reaction equation

HRID 332599 reaction equation
C([O:5][C:6](=[O:27])[C:7]([CH3:26])=[CH:8][C:9]1[S:10][C:11]([C:14]([O:16][C:17]2[CH:22]=[CH:21][C:20]([C:23](=[NH:25])[NH2:24])=[CH:19][CH:18]=2)=[O:15])=[CH:12][CH:13]=1)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[C:23]([C:20]1[CH:21]=[CH:22][C:17]([O:16][C:14]([C:11]2[S:10][C:9](/[CH:8]=[C:7](\[CH3:26])/[C:6]([OH:27])=[O:5])=[CH:13][CH:12]=2)=[O:15])=[CH:18][CH:19]=1)(=[NH:24])[NH2:25]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866733173-[5-(4-Amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester

Product 1

HCID 86673318(2E)-3-[5-(4-amidinophenoxycarbonyl)-thiophen-2-yl]-2-methylpropenoic acid trifluoroacetic acid salt

Procedure

To 3-[5-(4-amidinophenoxycarbonyl)thiophen-2-yl]-2-methylpropenoic acid tert-butyl ester (0.63 g) was added trifluoroacetic acid (5 mL), and the mixture was stirred for 30 minutes. The solvent was evaporated to give the title compound (0.62 g).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-9592999c9052485492e5b7c9e6074540
Source dataset
uspto-grants-2014_11
Patent number
US08877805B2

Reaction notes

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