反应详情

To a solution of 1 g 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester in 15 ml THF 314 mg LiBH4 were added cautiously. Then the reaction mixture was stirred for 16 h, quenched with diluted HCl and filtered through a chem elut® cartridge by elution with ethyl acetate and DCM. After concentration under reduced pressure the crude residue was directly subjected to the next reaction step. Yield: 800 mg.

1. customquenched with diluted HCl
2. filtrationfiltered through a chem elut® cartridge by elution with ethyl acetate and DCM
3. concentrationAfter concentration under reduced pressure the crude residue
4. customwas directly subjected to the next reaction step