反应详情

温度

70 °C

To a solution containing approx. 2.5 g 3-[2-(2-Methoxy-ethoxy)-ethoxy]-propyne, 2.8 g Diazo-acetic acid tert-butyl ester were added and the mixture was heated to 70° C. for 5 days. Then the solution was concentrated under reduced pressure and directly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient. Yield: 1.7 g.

1. additionwere added
2. concentrationThen the solution was concentrated under reduced pressure
3. customdirectly purified by chromatography on silica eluting with a n-heptane/ethyl acetate gradient