Potassium Carbonate → Methyl 4-((3-benzoylphenoxy)methyl)benzoate

Participants

Reaction Steps

To a stirred solution of 3-hydroxybenzophenone (1.00 g, 5.04 mmol) in dimethyl formamide (10 mL), was added potassium carbonate (1.05 g, 7.61 mmol), and the mixture was stirred for 10 minutes at room temperature. Methyl 4-bromobenzoate (1.30 g, 6.05 mmol) in dimethyl formamide (5 mL) was added, and the reaction mixture allowed to stir at room temperature for 16 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with brine, dried (MgSO4), and concentrated under reduced pressure. The crude material was purified by silica gel chromatography eluting with 0-17% ethyl acetate in iso-hexane to afford the title compound (1.64 g, 99%).

Provenance & Evidence