反应详情

To a stirred solution of 3-hydroxybenzophenone (1.00 g, 5.04 mmol) in dimethyl formamide (10 mL), was added potassium carbonate (1.05 g, 7.61 mmol), and the mixture was stirred for 10 minutes at room temperature. Methyl 4-bromobenzoate (1.30 g, 6.05 mmol) in dimethyl formamide (5 mL) was added, and the reaction mixture allowed to stir at room temperature for 16 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with brine, dried (MgSO4), and concentrated under reduced pressure. The crude material was purified by silica gel chromatography eluting with 0-17% ethyl acetate in iso-hexane to afford the title compound (1.64 g, 99%).

1. stirringto stir at room temperature for 16 hours
2. extractionextracted with ethyl acetate
3. extractionThe organic extract
4. washwas washed with brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated under reduced pressure
7. customThe crude material was purified by silica gel chromatography
8. washeluting with 0-17% ethyl acetate in iso-hexane