Methyl bromoacetate → Methyl 2-(3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)acetate

HRID 332686Notes

Reaction equation

HRID 332686 reaction equation
OC1C=C([N:8]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])C=CC=1.Br[CH2:24][C:25]([O:27][CH3:28])=[O:26].BrCCC[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH:38]1[O:42]CCO1>>[C:11]([O:10][C:9]([NH:8][CH:16]([C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[C:36]1[CH:37]=[C:38]([CH:33]=[CH:34][CH:35]=1)[O:42][CH2:24][C:25]([O:27][CH3:28])=[O:26])=[O:15])([CH3:12])([CH3:13])[CH3:14]

Participants

4

Reactant 3

HCID 60984Methyl bromoacetateHCID 118323182-(8-Bromooctyl)-1,3-dioxolaneHCID 86676908Tert-butyl(3-hydroxyphenyl)(phenyl)methylcarbamate

Product 1

HCID 71093308Methyl 2-(3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)acetate

Procedure

The title compound was prepared as described in Example 1 Step 1 with tert-butyl (3-hydroxyphenyl)(phenyl)methylcarbamate and methyl bromoacetate replacing 3-hydroxybenzophenone and 2-(8-bromooctyl)-1,3-dioxolane, respectively

Sources & evidence

ORD record
ord-4d033502cdec4788872a9556c752f2d9
Source dataset
uspto-grants-2014_11
Patent number
US08877774B2

Reaction notes

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