HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(1,3-Dioxolan-2-yl)propyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)-benzoate hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 3-(1,3-Dioxolan-2-yl)propyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)-methyl)phenoxy)methyl)benzoate | HCID 71093448 | — |
| Product | 3-(1,3-Dioxolan-2-yl)propyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)-benzoate hydrochloride | HCID 71256853 | 100% |
Reaction Steps
Hydrogen chloride in dioxan (4.0 M, 6 mL, 24 mmol) was added to 3-(1,3-dioxolan-2-yl)propyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)-methyl)benzoate (0.756 g, 1.38 mmol), and the resultant solution was stirred at ambient temperature for 2 hours. The solvent was evaporated at reduced pressure to afford the title compound (0.750 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08877774B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-b7f8ee1129cd4599bd732b5aa3981b34 |
| Source note | uspto-grants-2014_11 |