Hydrochloric Acid → 3-(1,3-Dioxolan-2-yl)propyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)-benzoate hydrochloride

HRID 332703Notes

Reaction equation

HRID 332703 reaction equation
[ClH:1].O1CCOCC1.C(OC([NH:15][CH:16]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:17]1[CH:18]=[C:19]([CH:39]=[CH:40][CH:41]=1)[O:20][CH2:21][C:22]1[CH:38]=[CH:37][C:25]([C:26]([O:28][CH2:29][CH2:30][CH2:31][CH:32]2[O:36][CH2:35][CH2:34][O:33]2)=[O:27])=[CH:24][CH:23]=1)=O)(C)(C)C>>[ClH:1].[NH2:15][CH:16]([C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)[C:17]1[CH:18]=[C:19]([CH:39]=[CH:40][CH:41]=1)[O:20][CH2:21][C:22]1[CH:38]=[CH:37][C:25]([C:26]([O:28][CH2:29][CH2:30][CH2:31][CH:32]2[O:33][CH2:34][CH2:35][O:36]2)=[O:27])=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 710934483-(1,3-Dioxolan-2-yl)propyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)-methyl)phenoxy)methyl)benzoate

Product 1

HCID 712568533-(1,3-Dioxolan-2-yl)propyl 4-((3-(amino(phenyl)methyl)phenoxy)methyl)-benzoate hydrochlorideYield 100%

Procedure

Hydrogen chloride in dioxan (4.0 M, 6 mL, 24 mmol) was added to 3-(1,3-dioxolan-2-yl)propyl 4-((3-(((tert-butoxycarbonyl)amino)(phenyl)methyl)phenoxy)-methyl)benzoate (0.756 g, 1.38 mmol), and the resultant solution was stirred at ambient temperature for 2 hours. The solvent was evaporated at reduced pressure to afford the title compound (0.750 g, 100%).

Workup

  1. customThe solvent was evaporated at reduced pressure

Sources & evidence

ORD record
ord-b7f8ee1129cd4599bd732b5aa3981b34
Source dataset
uspto-grants-2014_11
Patent number
US08877774B2

Reaction notes

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