反应详情

温度

80 °C

To a solution of 3-(1,3-dioxolan-2-yl)propyl 4-cyanobenzoate (1.00 g, 4.38 mmol) in ethanol (5 mL), was added hydroxylamine (50% aqueous solution, 5 mL), and the mixture heated at 80° C. for 4 hours. The reaction was diluted with saturated brine and extracted with ethyl acetate (×3). The combined organic fractions were dried with magnesium sulphate, and the solvent evaporated at reduced pressure. The material was used directly in the next step without further purification.

1. extractionextracted with ethyl acetate (×3)
2. dry with materialThe combined organic fractions were dried with magnesium sulphate
3. customthe solvent evaporated at reduced pressure
4. customThe material was used directly in the next step without further purification