Hydrochloric Acid → (R)-2-Amino-2-phenylacetamide hydrochloride

HRID 332800Notes

Reaction equation

HRID 332800 reaction equation
[NH2:1][C:2](=[O:18])[C@H:3]([NH:10]C(=O)OC(C)(C)C)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:19]>O1CCOCC1>[ClH:19].[NH2:10][C@H:3]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[C:2]([NH2:1])=[O:18]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10944841(R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate

Product 1

HCID 16216957(R)-2-Amino-2-phenylacetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The solid (R)-tert-butyl 2-amino-2-oxo-1-phenylethylcarbamate (446 mg) was dissolved in dioxane (5 mL), aq. 6N HCl (8 mL) was added. After being stirred at room temperature for 20 h, the mixture was concentrated in vacuo to give (R)-2-amino-2-phenylacetamide hydrochloride as a solid (329 mg).

Workup

  1. concentrationthe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-e2c82af006984bc1a02c1c30260d85c6
Source dataset
uspto-grants-2014_11
Patent number
US08877760B2

Reaction notes

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