反应详情

To a solution of crude 3-aminothiophene-2-carbothioamide in MeOH (5 mL) was added H2O2 (30%, 0.6 mL), after stirring at room temperature for 15 min, it was concentrated to remove most of MeOH, and then diluted with EtOAC, organic layer was washed with brine, concentrated to give crude pdt, purification by column chromatography (DCM/EtOAC=3:1) gave thieno[3,2-c]isothiazol-3-amine (334 mg).

1. concentrationit was concentrated
2. customto remove most of MeOH
3. additiondiluted with EtOAC, organic layer
4. washwas washed with brine
5. concentrationconcentrated
6. customto give crude
7. custompdt, purification by column chromatography (DCM/EtOAC=3:1)