Imidazole → HCID 68854444, Verbindung

HRID 333022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 333022
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1F)[C:5]#[N:6].[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[H-].[Na+].O>CN(C)C=O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]#[N:6])[CH:7]=[CH:8][C:9]=1[N:11]1[CH:15]=[CH:14][N:13]=[CH:12]1

Komponenten

6

Edukt 4

HCID 795ImidazoleHCID 962WaterHCID 24758Sodium hydrideHCID 1235793-Bromo-4-fluorobenzonitrile

Produkt 1

HCID 68854444HCID 68854444, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

3-Bromo-4-fluorobenzonitrile (10.0 g, 50 mmol, 1 eq) and imidazole (5.1 g, 75 mmol, 1.5 eq) are dissolved in dimethylformamide (100 ml) and carefully admixed with sodium hydride (60% in mineral oil, 3.0 g, 75 mmol, 1.5 eq) under nitrogen at room temperature. The mixture is stirred at 100° C. for 4 hours. After cooling to room temperature, water (10 ml) is added and the mixture is evaporated to dryness. The residue is washed with water and petroleum ether and purified by column chromatography (silica gel, methyl tert-butyl ether/ethyl acetate gradient).

Aufarbeitung

  1. temperatureAfter cooling to room temperature
  2. customthe mixture is evaporated to dryness
  3. washThe residue is washed with water and petroleum ether
  4. custompurified by column chromatography (silica gel, methyl tert-butyl ether/ethyl acetate gradient)

Quellen und Nachweise

ORD-Eintrag
ord-ebad00ea2dd64a198e30f0f28e1bf016
Quelldatensatz
uspto-grants-2014_11
Patentnummer
US08877937B2

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