1,3-Propanediamine → HCID 66835428, compound

HRID 333059Notes

Reaction equation

HRID 333059 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[CH:3]=1.[NH2:9][CH2:10][CH2:11][CH2:12][NH2:13]>>[ClH:1].[CH3:8][C:4]1[CH:3]=[C:2]([NH:9][CH2:10][CH2:11][CH2:12][NH2:13])[CH:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 4281,3-PropanediamineHCID 5813924-Chloro-2-methylpyridine

Product 1

HCID 66835428HCID 66835428, compound

Conditions

Temperature
180 °C

Procedure

4-Chloro-2-picoline (441 μl, 4 mmol) was mixed with 1,3-diaminopropane (1.67 ml, 20 mmol) and stirred in a closed vessel at 180° C. under microwave heating for one hour. The solvent was removed under reduced pressure, toluene was added to the residue and the mixture was evaporated to dryness under reduced pressure to yield 1.076 of a solid. MS (APCI) m/z=165.8 [M+H]+.

Workup

  1. temperatureheating for one hour
  2. customThe solvent was removed under reduced pressure, toluene
  3. additionwas added to the residue
  4. customthe mixture was evaporated to dryness under reduced pressure
  5. customto yield 1.076 of a solid

Sources & evidence

ORD record
ord-c1770e54e5614992a10835eeaf34b052
Source dataset
uspto-grants-2014_11
Patent number
US08877934B2

Reaction notes

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