HCID 67194541, compound → HCID 67190295, compound

HRID 333211Notes

Reaction equation

HRID 333211 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[C:18](=[O:19])[CH:17]3[CH:20]([C:25]([OH:27])=[O:26])[CH:21]4O[C:16]3([CH:23]=[CH:22]4)[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl>[O:19]=[C:18]1[C:17]2[C:20]([C:25]([OH:27])=[O:26])=[CH:21][CH:22]=[CH:23][C:16]=2[CH2:15][N:14]1[CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 1

HCID 67194541HCID 67194541, compound

Product 1

HCID 67190295HCID 67190295, compoundYield 92.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

3-(1-Tert-butoxycarbonyl-piperidin-4-yl)-4-oxo-10-oxa-3-aza-tricyclo[5.2.1.0*1,5*]dec-8-ene-6-carboxylic acid (6.35 g, 16.8 mmol) was dissolved in 37% hydrochloric acid (80 mL) and the resulted solution was refluxed for 3 hours. The solvent was removed under reduced pressure and the residue was diluted with methanol and decanted in order to obtained the desired product as a white solid (4.06 g, 82%).

Workup

  1. temperaturethe resulted solution was refluxed for 3 hours
  2. customThe solvent was removed under reduced pressure
  3. additionthe residue was diluted with methanol
  4. customdecanted in order

Sources & evidence

ORD record
ord-c7c30a52511c43e89b0f42d65750d866
Source dataset
uspto-grants-2014_11
Patent number
US08877944B2

Reaction notes

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