Hydrochloric Acid → HCID 67193005, compound

HRID 333214Notes

Reaction equation

HRID 333214 reaction equation
[Cl:1][C:2]1([Cl:12])[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.Cl>CC(C)=O.O>[Cl:1][C:2]1([Cl:12])[CH2:11][CH2:10][C:5](=[O:6])[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67191775HCID 67191775, compound

Product 1

HCID 67193005HCID 67193005, compoundYield 78%

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

To a solution of 8,8-dichloro-1,4-dioxaspiro[4.5]decane (0.27 g, 1.28 mmol) in acetone (3.5 mL), aqueous 2N hydrochloric acid (5 mL) was added and the reaction mixture was stirred at room temperature overnight, diluted with water and extracted twice with diethyl ether. The combined organic phases were washed with water, brine, dried over sodium sulfate and evaporated to dryness. The resulting crude 4,4-dichlorocyclohexanone, obtained as a white solid, was used in the next steps without any further purification (0.17 g, 78% yield).

Workup

  1. extractionextracted twice with diethyl ether
  2. washThe combined organic phases were washed with water, brine
  3. dry with materialdried over sodium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-5028a3d22acc4cadaccf57b33b7a1227
Source dataset
uspto-grants-2014_11
Patent number
US08877944B2

Reaction notes

Loading…