反应详情

2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-5-chloro-7-iodo-2,3-dihydro-1H-isoindol-1-one (80 mg, 0.16 mmol) and copper(I) cyanide (22 mg, 0.24 mmol) were dissolved in N,N-dimethylformamide (1 mL) and the resulted solution was refluxed under nitrogen atmosphere for 3 hours. The solvent was removed under reduced pressure and the residue was diluted with dichloromethane and washed with 15% ammonium hydroxide. Organic phase was dried over sodium sulfate, filtered and evaporated. Column chromatography (dichloromethane/ethanol:95/5) afforded title compound (46 mg, 72% yield).

1. temperaturethe resulted solution was refluxed under nitrogen atmosphere for 3 hours
2. customThe solvent was removed under reduced pressure
3. additionthe residue was diluted with dichloromethane
4. washwashed with 15% ammonium hydroxide
5. dry with materialOrganic phase was dried over sodium sulfate
6. filtrationfiltered
7. customevaporated