反应详情

Methyl 3-fluoro-2-iodo-6-methylbenzoate (440 mg, 1.49 mmol) and copper(I) cyanide (200 mg, 2.24 mmol) were dissolved in N,N-dimethylformamide (5.5 mL) and the resulted solution was refluxed under nitrogen atmosphere for 3 hours. The solvent was removed under reduced pressure and the residue was diluted with dichloromethane and washed with 15% ammonium hydroxide. Organic phase was dried over sodium sulfate, filtered and evaporated. Column chromatography (n-hexane/ethyl acetate: 7/3) afforded title compound (210 mg, 73% yield).

1. temperaturethe resulted solution was refluxed under nitrogen atmosphere for 3 hours
2. customThe solvent was removed under reduced pressure
3. additionthe residue was diluted with dichloromethane
4. washwashed with 15% ammonium hydroxide
5. dry with materialOrganic phase was dried over sodium sulfate
6. filtrationfiltered
7. customevaporated