Hydrochloric Acid → HCID 53321058, compound

HRID 333233Notes

Reaction equation

HRID 333233 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([C:15]([N:17]([CH3:19])[CH3:18])=O)[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8].Cl>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH2:15][N:17]([CH3:19])[CH3:18])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68673029HCID 68673029, compound

Product 1

HCID 53321058HCID 53321058, compound

Procedure

The title compound was synthesized from 1-(3,4-dichlorophenyl)-N,N-dimethylcyclohexanecarboxamide (71 mg, 0.24 mmol) using General Procedure E followed by HCl salt formation. The crude HCl salt was recrystallized from CH3CN (3 mL) to afford the product as an off-white solid. HPLC Rt=8.70 min; 1H NMR (400 mHz, MeOH-d4) 7.72 (d, J=2.44 Hz, 1H), 7.63 (d, J=8.55 Hz, 1H), 7.49 (dd, J=2.44, 8.55 Hz, 1 H), 3.47 (bs, 2H), 3.32 (s, 6H), 2.28-2.24 (bs, 2H), 1.81-1.39 (m, 8H); LCMS 9.79 min, (M+1)+ [email protected] min.

Workup

  1. customThe crude HCl salt was recrystallized from CH3CN (3 mL)

Sources & evidence

ORD record
ord-3bd559ca58b8465d8a6e9b8986dda210
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

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