Hydrochloric Acid → HCID 68673901, compound

HRID 333246Notes

Reaction equation

HRID 333246 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([NH:16][CH3:17])=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH2:14][NH:16][CH3:17])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 68674855HCID 68674855, compound

Product 1

HCID 68673901HCID 68673901, compoundYield 121.6%

Procedure

The title compound was synthesized from 1-(4-chlorophenyl)-N-methylcyclohexanecarboxamide (278 mg, 1.11 mmol) using General Procedure E, followed by HCl salt formation to give pure (1-(4-chlorophenyl)cyclohexyl)-N-methylmethanamine hydrochloride as an off-white solid (185 mg, 70%). HPLC Rt=8.38 min; 1H NMR (400 mHz, MeOH-d4) 7.39 (s, 4H), 3.10 (s, 2H), 2.52 (s, 3H), 2.19-2.16 (m, 2H), 1.65-1.49 (m, 6H), 1.37-1.30 (m, 4H); LC-MS 7.49 min, (M+1)+0 238 @ 7.63 min.

Sources & evidence

ORD record
ord-0823ab5ab10c4435a5f8b0bd2f07d4c5
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

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