反应详情

1-Benzyl 4-tert-butyl 2-(biphenyl-4-ylmethyl)succinate (500 mg, 1.161 mmol) was dissolved in 10 mL of EtOAc and hydrogenated with 10% Pd/C at room temperature. After 4 hours of the hydrogenation, the mixture was concentrated under reduced pressure. The obtained residue was purified by flash chromatography (silica gel, 2 to 5% MeOH/DCM) and gave the title compound: 296 mg (yield: 93%). LCMS (condition G): 339.1 (M−1); retention time=0.70 min.

1. concentrationthe mixture was concentrated under reduced pressure
2. customThe obtained residue was purified by flash chromatography (silica gel, 2 to 5% MeOH/DCM)