Trifluoroacetic acid methylene chloride → 4-Ethoxycarbonyl-4-ethylpiperidine trifluoroacetate

HRID 333428Notes

Reaction equation

HRID 333428 reaction equation
[CH2:1]([C:3]1([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:8][CH2:7][N:6](C(OC(C)(C)C)=O)[CH2:5][CH2:4]1)[CH3:2].ClCCl.[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>>[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27].[CH2:19]([O:18][C:16]([C:3]1([CH2:1][CH3:2])[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)=[O:17])[CH3:20]

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 53393415Ethyl 1-Boc-4-ethyl-4-piperidine carboxylate

Product 1

HCID 669880094-Ethoxycarbonyl-4-ethylpiperidine trifluoroacetateYield 73%

Procedure

183 mg (0.64 mmol) of tert-butyl 4-ethyl-4-ethoxycarbonylpiperidine-1-carboxylate are diluted in 4 mL of an 8/2 dichloromethane/trifluoroacetic acid mixture. The solution is stirred at room temperature for 1 hour and the solvents are then evaporated off. 140 mg of 4-ethoxycarbonyl-4-ethylpiperidine trifluoroacetate in the form of an oil are obtained in a yield of 73%.

Workup

  1. customthe solvents are then evaporated off

Sources & evidence

ORD record
ord-d40fb2bcff7d4674b1093f8ed8aae5a9
Source dataset
uspto-grants-2014_11
Patent number
US08877968B2

Reaction notes

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