Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 4-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate)
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | 3-(1-trityl-1H-imidazol-4-yl)propan-1-amine | HCID 15345825 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 4-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate) | HCID 86659209 | 61% |
반응 단계
0.5 g (1.4 mmol) of 3-(1-trityl-1H-imidazol-4-yl)propylamine is dissolved in 8 mL of dichloromethane with 2 mL of trifluoroacetic acid. After 2 hours, the medium is concentrated. The beige-coloured solid obtained is taken up in EtOAc and water, and the aqueous phase is then concentrated to dryness. 0.3 g of 4-(3-aminopropyl)-1H-imidazol-1-ium bis(trifluoroacetate) is obtained in a yield of 61%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08877968B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-e0835d61a944432aab08d260aafbdc27 |
| 출처 메모 | uspto-grants-2014_11 |