反应详情

温度

30 °C

Ethanol (2 mL), acetone (15 mL), 1 N HCl (0.3 mL), and deionized water (0.3 mL) were added to amorphous ((S)-1-{(S)-2-[4-(4′-{[6-((2R,5S)-2,5-dimethyl-4-methylcarbamoyl-piperazin-1-yl)-pyridine-3-carbonyl]-amino}-2′-trifluoromethoxy-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester diHCl (650 mg) and the reaction solution was stirred at 30° C. for 18 h to give a crystalline slurry and then stirred for 48 h at RT. The thickened slurry was filtered and air-dried for 2 h to provide the title compound (586 mg).

1. customto give a crystalline slurry
2. stirringstirred for 48 h at RT
3. filtrationThe thickened slurry was filtered
4. customair-dried for 2 h