反应详情

温度

50 °C

The Tramadol Resin Complex was prepared by first dissolving 500 g of tramadol HCl in 8 liters of purified water, and then slowly adding 1,345 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content around 20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

1. additionslowly adding 1,345 g of AMBERLITE™
2. additionThe dispersion was mixed for 4 hours and upon completion
3. custombefore decanting the supernatant
4. customThe wet resin complex was then dried in a VWR™ convection oven
5. additionKOLLICOAT™ SR-30D polymer (467 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. customto form a uniform mass
7. customThe wet mass was again dried in a 50° C
8. customThe semi-dried granules were then milled through a 40 mesh screen
9. customcontinued drying under 50° C. until the moisture content
10. customThe dried granules were then milled through a 40 mesh screen