反应详情

Palladium hydroxide (20%, 0.75 g, 1.068 mmol) was added to a Parr hydrogenation bottle, and the bottle was purged with nitrogen. Next, 4-azidodibenzo[b,d]furan (7.39 g, 35.3 mmol) and 150 mL ethanol were added, and the reaction mixture was hydrogenated on Parr hydrogenator overnight. The reaction mixture was filtered through a pad of Celite®, and the Celite® was washed with dichloromethane. The filtrate was evaporated, and the residue was purified by column chromatography eluting with 50% dichloromethane/hexanes (5.58 g, 86%).

1. customthe bottle was purged with nitrogen
2. customwas hydrogenated on Parr hydrogenator overnight
3. filtrationThe reaction mixture was filtered through a pad of Celite®
4. washthe Celite® was washed with dichloromethane
5. customThe filtrate was evaporated
6. customthe residue was purified by column chromatography
7. washeluting with 50% dichloromethane/hexanes (5.58 g, 86%)