Hydrochloric Acid → HCID 18934956, compound

HRID 3336Notes

Reaction equation

HRID 3336 reaction equation
[C:1]([CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[O:9])#[N:2].[OH-].[Na+].Cl.[Cl-].[Na+]>C(O)C.[Ni]>[NH2:2][CH2:1][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[O:9]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 10703101N-(6-cyanohexanoyl)-glycine

Product 1

HCID 18934956HCID 18934956, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

8.2 g (41.4·10-3 mol) of N-(6-cyanohexanoyl)-glycine are dissolved in 100 ml of ethanol, and 60 ml of 1M sodium hydroxide solution and 800 mg of Raney nickel are added. The mixture is then stirred under a hydrogen atmosphere, at room temperature and under a pressure of 3.5·105Pa, for 8 hours. When the reaction has ended, 20 ml of 1M hydrochloric acid are added and the mixture is concentrated under reduced pressure to give 10.2 g of a white pasty solid, which contains the expected salt and sodium chloride and which can be used without further purification in the next step.

Workup

  1. concentrationthe mixture is concentrated under reduced pressure
  2. customto give 10.2 g of a white pasty solid, which
  3. customcan be used without further purification in the next step

Sources & evidence

ORD record
ord-ae97e9d0be094c7d859d65239405a8ff
Source dataset
uspto-grants-1998_03
Patent number
US05733928

Reaction notes

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