Hydrochloric Acid → 1-(4-Aminophenyl)ethan-1-one--hydrogen chloride (1/1)

HRID 333633Notes

Reaction equation

HRID 333633 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.[ClH:11]>C1C=CC=CC=1>[ClH:11].[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 7468p-Aminoacetophenone

Product 1

HCID 233338311-(4-Aminophenyl)ethan-1-one--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

p-aminoacetophenon (Aldrich Corp., USA) is added to benzene, and hydrochloric acid gas is passed. The obtained precipitation is filtered and recrystallized with isopropanol to obtain p-aminoacetophenon hydrochloride. The obtained p-aminoacetophenon hydrochloride is dissolved in a 20% aqueous ethanol solution, and made it acidic by adding concentrated hydrochloric acid on an ice bath. An aqueous sodium nitrite solution is dropped and urea treatment is carried out to obtain a diazonium salt solution.

Workup

  1. customThe obtained precipitation
  2. filtrationis filtered
  3. customrecrystallized with isopropanol

Sources & evidence

ORD record
ord-ec3fc67dff0a4eeab161d1cf0b35e4f2
Source dataset
uspto-grants-2014_11
Patent number
US08883504B2

Reaction notes

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