反应详情

Potassium hydroxide and 2-(4-acetyl-phenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinoline-1-ylidene)-acetamide (Asinex Corp., Russia) are added to ethanol, and the mixture is refluxed under heating. The refluxed product is cooled to room temperature and, then, added with distilled water, and further added with hydrochloric acid to make the pH neutral, followed by extracting the reaction product with diethylether. The reaction product is dried by using anhydrous sodium sulfate and filtered and, then, the solvent is removed by reducing the pressure. The residue containing the reaction product is purified by column chromatography to obtain the title compound.

1. temperaturethe mixture is refluxed
2. temperatureunder heating
3. extractionby extracting the reaction product with diethylether
4. customThe reaction product is dried
5. filtrationfiltered
6. customthe solvent is removed
7. additionThe residue containing the reaction product
8. customis purified by column chromatography