Methanol → 2-(4-Aminophenyl)-7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b]-[1,3]benzothiazole

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	7-[2-(4-Morpholinyl)ethoxy]-2-(4-nitrophenyl)imidazo[2,1-b]benzothiazole	HCID 44598716	—
Reactant	HCID 178418361	HCID 178418361	—
Catalyst	Nickel	HCID 935	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-(4-Aminophenyl)-7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b]-[1,3]benzothiazole	HCID 44598669	—

Reaction Steps

Intermediate 3 is dissolved into Methanol and THF and placed in a Hydrogenator. Raney Nickel is added and the vessel is pressurized with Hydrogen and stirred for >24 hrs. The reaction mixture is concentrated to a thick paste and diluted with Methyl tert-butyl ether. The resulting solids are filtered and washed with Methyl tert-butyl ether and dried under vacuum to give Intermediate 4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08883783B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-7d04506a4eca445d968eab0acfc761e4
Source note	uspto-grants-2014_11