反应详情

Intermediate 3 is dissolved into Methanol and THF and placed in a Hydrogenator. Raney Nickel is added and the vessel is pressurized with Hydrogen and stirred for >24 hrs. The reaction mixture is concentrated to a thick paste and diluted with Methyl tert-butyl ether. The resulting solids are filtered and washed with Methyl tert-butyl ether and dried under vacuum to give Intermediate 4.

1. concentrationThe reaction mixture is concentrated to a thick paste
2. additiondiluted with Methyl tert-butyl ether
3. filtrationThe resulting solids are filtered
4. washwashed with Methyl tert-butyl ether
5. customdried under vacuum