反应详情

温度

50 °C

At 20 to 40° C. 52 g (0.53 mol) phosgene are piped into a solution of 121 g (0.47 mol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 800 mL pyridine. The reaction mixture is heated to 50° C. for 2 hours, then poured onto ice and acidified with conc. hydrochloric acid. A reddish-brown solid is isolated which is repeatedly recrystallised from ethanol with the addition of activated charcoal.

1. customAt 20 to 40° C
2. additionpoured onto ice
3. customA reddish-brown solid is isolated which
4. customis repeatedly recrystallised from ethanol with the addition of activated charcoal