反应详情

A mixture of 2-[3-(benzyloxy)propyl]-3-methyl-3H-imidazo[4,5-b]pyridine (1.8 g), 20% palladium hydroxide on carbon (2.35 g, containing water (50%)), and formic acid (8.45 mL) in methanol (84.5 mL) was refluxed for 6 hr. The mixture was allowed to cool to room temperature, and the catalyst was filtered off. The obtained filtrate was concentrated under reduced pressure. The residue was purified by NH silica gel column chromatography (ethyl acetate/hexane) to give the title compound (1.0 g).

1. temperaturewas refluxed for 6 hr
2. filtrationthe catalyst was filtered off
3. concentrationThe obtained filtrate was concentrated under reduced pressure
4. customThe residue was purified by NH silica gel column chromatography (ethyl acetate/hexane)