2-Bromoethyl methyl ether → HCID 57474048, compound

HRID 333785Notes

Reaction equation

HRID 333785 reaction equation
[CH3:1][O:2][CH2:3][CH2:4]Br.[Cl:6][C:7]1[CH:8]=[C:9]([OH:28])[CH:10]=[CH:11][C:12]=1[CH:13]([CH3:27])[C:14]([OH:26])([C:19]1[CH:24]=[N:23][C:22]([CH3:25])=[CH:21][N:20]=1)[C:15]([F:18])([F:17])[F:16]>>[Cl:6][C:7]1[CH:8]=[C:9]([O:28][CH2:4][CH2:3][O:2][CH3:1])[CH:10]=[CH:11][C:12]=1[CH:13]([CH3:27])[C:14]([C:19]1[CH:24]=[N:23][C:22]([CH3:25])=[CH:21][N:20]=1)([OH:26])[C:15]([F:18])([F:16])[F:17]

Participants

3

Reactant 2

HCID 809722-Bromoethyl methyl etherHCID 574212313-Chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol

Product 1

HCID 57474048HCID 57474048, compound

Procedure

The title compound was prepared in analogy to Example 74 from 2-bromoethyl methyl ether and 3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenol (Example 72). MS (m/e)=405.3 (MH+).

Sources & evidence

ORD record
ord-6879f8cf5f7949d6be977994f2ef0c15
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

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