Hydrogen Bromide → HCID 57421251, compound

HRID 333793Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:23])[C:11]([C:17]1[CH:22]=[CH:21][N:20]=[CH:19][CH:18]=1)([OH:16])[C:12]([F:15])([F:14])[F:13].Br>>[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:23])[C:11]([OH:16])([C:17]1[CH:18]=[CH:19][N:20]=[CH:21][CH:22]=1)[C:12]([F:15])([F:13])[F:14]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 57421250HCID 57421250, compound

Product 1

HCID 57421251HCID 57421251, compound

Procedure

The title compound was prepared in analogy to Example 72 from 3-(2-chloro-4-methoxy-phenyl)-1,1,1-trifluoro-2-pyridin-4-yl-butan-2-ol (Example 104) by treatment with aqueous HBr. MS (m/e)=332.1 (MH+).

Sources & evidence

ORD record: ord-f20e6b2625ec4176a5bf83bfc7dc05e9
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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