Hydrogen Bromide → HCID 57421254, compound

HRID 333794Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:27])[C:11]([C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:20]=[N:19][CH:18]=1)([OH:16])[C:12]([F:15])([F:14])[F:13].Br>>[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:27])[C:11]([C:17]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[N:20]=[N:19][CH:18]=1)([OH:16])[C:12]([F:15])([F:13])[F:14]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 57421253HCID 57421253, compound

Product 1

HCID 57421254HCID 57421254, compound

Procedure

The title compound was prepared in analogy to Example 72 from 3-(2-chloro-4-methoxy-phenyl)-2-cinnolin-4-yl-1,1,1-trifluoro-butan-2-ol (Example 107) by treatment with aqueous HBr. MS (m/e)=383.2 (MH+).

Sources & evidence

ORD record: ord-241cb88d90b44bfa8de28be9c1afd8ef
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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