Hydrogen Bromide → 3-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-pyrazolo[1,5-a]pyridin-3-yl-propyl)-phenol

HRID 333795Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([O:8]C)[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:26])[C:11]([C:17]1[CH:18]=[N:19][N:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=12)([OH:16])[C:12]([F:15])([F:14])[F:13].Br>>[Cl:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[CH:10]([CH3:26])[C:11]([OH:16])([C:17]1[CH:18]=[N:19][N:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=12)[C:12]([F:15])([F:13])[F:14]

Participants

Reactant 2

HCID 260Hydrogen Bromide

HCID 57421255HCID 57421255, compound

Product 1

HCID 252544473-Chloro-4-(3,3,3-trifluoro-2-hydroxy-1-methyl-2-pyrazolo[1,5-a]pyridin-3-yl-propyl)-phenol

Procedure

The title compound was prepared in analogy to Example 72 from 3-(2-chloro-4-methoxy-phenyl)-1,1,1-trifluoro-2-pyrazolo[1,5-a]pyridin-3-yl-butan-2-ol (Example 109) by treatment with aqueous HBr. MS (m/e)=371.1 (MH+).

Sources & evidence

ORD record: ord-756492dc67eb494cb8290447ac204af2
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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