Iodoethane → 5-[2-(2,4-Dichloro-phenyl)-propionyl]-1-ethyl-1H-pyridin-2-one

HRID 333866Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:19])[C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[NH:16][CH:17]=1)=[O:11].I[CH2:21][CH3:22]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]([CH3:19])[C:10]([C:12]1[CH:13]=[CH:14][C:15](=[O:18])[N:16]([CH2:21][CH3:22])[CH:17]=1)=[O:11]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 574213545-[2-(2,4-Dichloro-phenyl)-propionyl]-1H-pyridin-2-one

Product 1

HCID 668132695-[2-(2,4-Dichloro-phenyl)-propionyl]-1-ethyl-1H-pyridin-2-one

Procedure

In analogy to Example 195, 5-[2-(2,4-dichloro-phenyl)-propionyl]-1H-pyridin-2-one (Example 201, step 4) was alkylated with iodoethane to give the title compound as a colorless oil. MS (m/e)=324.2 [M+H+].

Sources & evidence

ORD record: ord-7e83f78891dc48a193bcaa7517fa5bce
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08883786B2

Reaction notes

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