Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | 1,1-Dimethylethyl 6-(8-((2-benzothiazolylamino)carbonyl)-3,4-dihydro-2(1H)-isoquinolinyl)-3-bromo-2-pyridinecarboxylate | HCID 59447615 | — |
| Reactant | HCID 178419781 | HCID 178419781 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 89999965 | HCID 89999965 | — |
Reaction Steps
To a mixture of Example 5D (200 mg), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane (28.9 mg) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (22 mg) in tetrahydrofuran (3 mL) was added (3-phenylpropyl)zinc(II) bromide (1.42 mL). The resulting suspension was heated in a Biotage microwave synthesizer at 100° C. for 30 minutes. The reaction mixture was filtered through a sintered glass funnel. The filtrate was concentrated, and the residue was purified by preparative TLC, eluting with 40% acetone in petroleum ether, to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08883784B2 |
|---|
| Source dataset | uspto-grants-2014_11 |
|---|
| ORD ID | ord-bc7647311ffc4b4c8853653bb9b3ea2e |
|---|
| Source note | uspto-grants-2014_11 |
|---|
