反应详情

温度

100 °C

To a mixture of Example 5D (200 mg), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane (28.9 mg) and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (22 mg) in tetrahydrofuran (3 mL) was added (3-phenylpropyl)zinc(II) bromide (1.42 mL). The resulting suspension was heated in a Biotage microwave synthesizer at 100° C. for 30 minutes. The reaction mixture was filtered through a sintered glass funnel. The filtrate was concentrated, and the residue was purified by preparative TLC, eluting with 40% acetone in petroleum ether, to provide the title compound.

1. filtrationThe reaction mixture was filtered through a sintered glass funnel
2. concentrationThe filtrate was concentrated
3. customthe residue was purified by preparative TLC
4. washeluting with 40% acetone in petroleum ether