反应详情

4-(4-Piperidyl)quinoline (0.1 mmol, 21 mg) was dissolved in dichloromethane (1 ml). Triethylamine (1 ml of a 0.12M solution in dichloromethane) was added, the solution was shaken for 30 seconds and (E)-4-methylpent-2-enoyl chloride was added (1 ml of a 0.12 M solution in dichloromethane. The mixture was shaken for one hour at room temperature and evaporated to dryness under reduced pressure. The residue was purified by preparative HPLC. 5.1 mg were obtained (0.017 mmol, 17%).

1. stirringThe mixture was shaken for one hour at room temperature
2. customevaporated to dryness under reduced pressure
3. customThe residue was purified by preparative HPLC
4. custom5.1 mg were obtained (0.017 mmol, 17%)