反应详情

2-Methyl-4-piperazin-1-yl-quinoline (227.3 mg, 1 mmol) was dissolved in anhydrous dichloromethane (7 ml), triethylamine was added (209 μl, 1.5 mmol), followed by methanesulfonyl chloride (85 μl, 1.1 mmol) which was added dropwise with ice-cooling. The mixture was diluted with dichloromethane and washed with 5% sodium bicarbonate solution. The wash solution was extracted with dichloromethane, the organic phases were combined and washed with 5% sodium bicarbonate solution, water and dried over magnesium sulfate. After evaporation of the solvent under reduced pressure 265 mg of a white foam were obtained (0.87 mmol, 87%) which was used directly in the next step.

1. additionwas added dropwise with ice-
2. temperaturecooling
3. washwashed with 5% sodium bicarbonate solution
4. extractionThe wash solution was extracted with dichloromethane
5. washwashed with 5% sodium bicarbonate solution, water
6. dry with materialdried over magnesium sulfate
7. customAfter evaporation of the solvent under reduced pressure 265 mg of a white foam
8. customwere obtained (0.87 mmol, 87%) which