反应详情

2-Methyl-7-(trifluoromethyl)quinolin-4-ol (1 g, 4.4 mmol) was heated in phosphoroxychloride (3 ml) for under reflux for one hour. The mixture was poured on ice and left at 4° C. overnight. The mixture was extracted with ethylacetate, the organic phase was washed with water, dried over sodium sulfate and evaporated to dryness under reduced pressure to yield 1.1 g (4.4 mmol, quantitative) which were used directly in the next step.

1. temperatureunder reflux for one hour
2. additionThe mixture was poured on ice
3. extractionThe mixture was extracted with ethylacetate
4. washthe organic phase was washed with water
5. dry with materialdried over sodium sulfate
6. customevaporated to dryness under reduced pressure
7. customto yield 1.1 g (4.4 mmol, quantitative) which