反应详情

tert-Butyl 3-(2-methoxy-2-oxo-ethyl)-4-(2-methyl-4-quinolyl)piperazine-1-carboxylate (239 mg, 0.28 mmol) was dissolved in dioxane (1 ml), combined with a solution of HCl in dioxane (4N, 4 ml, 16 mmol) and stirred overnight. The mixture was diluted with diethylether, the precipitate was collected by filtration and dissolved in DCM. The solution was washed with a saturated solution of sodium bicarbonate and dried over sodium sulfate. The solvent was removed under reduced pressure, the residue was triturated with diethylether to yield 85 mg of a yellow solid (0.253 mmol, 72%).

1. filtrationthe precipitate was collected by filtration
2. dissolutiondissolved in DCM
3. washThe solution was washed with a saturated solution of sodium bicarbonate
4. dry with materialdried over sodium sulfate
5. customThe solvent was removed under reduced pressure
6. customthe residue was triturated with diethylether