反应详情

4-Chloro-7-(trifluoromethyl)quinoline (2.3 g, 10 mmol) was dissolved in dipropyleneglycolmonomethyl ether (10 ml) together with piperazine (6.8 g, 0.1 mol) and glacial acetic acid (0.3 ml) and heated at reflux for 2 days. The mixture was concentrated under reduced pressure and the residue was purified by column chromatography (silica, gradient from ethylacetate to methanol containing 1% ammonia) to yield a yellow crystalline solid (1.2 g, 43%).

1. temperatureheated
2. temperatureat reflux for 2 days
3. concentrationThe mixture was concentrated under reduced pressure
4. customthe residue was purified by column chromatography (silica, gradient from ethylacetate to methanol containing 1% ammonia)