反应详情

(E)-4-methyl-1-[4-[7-(trifluoromethyl)-4-quinolyl]piperazin-1-yl]hex-2-en-1-one (20 mg, 0.049 mmol) was dissolved in THF (1 ml), Lawesson's reagent (20 mg, 0.051 mmol) was added in one portion and the resulting mixture was stirred overnight at room temperature. The volatiles were removed under reduced pressure and the residue was purified by preparative HPLC (gradient of water containing 0.1% NH3 and acetonitrile) to yield 5.4 mg (0.013 mmol, 25%).

1. customThe volatiles were removed under reduced pressure
2. customthe residue was purified by preparative HPLC (gradient of water containing 0.1% NH3 and acetonitrile)
3. customto yield 5.4 mg (0.013 mmol, 25%)